A brief description from BGN's own Andrea "Liga" Ligabue (Boardgame News):

This game is the sequel to Lupus in Tabula; the Tabula inhabitants have moved into the city, but there is a little problem—the werewolves have moved there, too! This game keeps the theme and part of the mechanism of the famous party-game precursor, but this time it's for 3-8 players. Note that Lupusburg isn't an expansion, although it is possible to combine parts of the two games.